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Clinical Studies

Isoflavones
The importance of isoflavones is widely appreciated and is currently the subject of intense research and discussions. Isoflavones appear to protect against hormone-related disorders such as breast cancer and prostate cancers.
The chemical structure of isoflavones is very similar to that of our own estrogen. Isoflavones can also increase estrogen activity. If during menopause the body's natural level of estrogen drops, isoflavones can compensate by binding to same receptor sites thereby easing menopause symptoms as a result.

The best way to consume isoflavones is in the form soy, so you can benefit from other healthy components of soy. Soy contains many types of isoflavones, but the most beneficial are genistein and daidzein. The highest amounts of isoflavones can be found in soy nuts and tempeh. Isoflavones are fairly stable. Under normal cooking methods, isoflavones are not destroyed.

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Biological Effects of Isoflavones in Young Women: Importance of the Chemical Composition of Soybean Products. British Journal of Nutrition, 1995; 75. Rationale for Use of Genestein - Containing Soy Matrices in Breast and Prostate.. Journal of Cellular Biochemistry. 1995; 22(suppl).

Growth and hormonal effects of soy. American Journal of Clinical Nutrition. 1998; 68 (suppl):1539S-40S. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. American Journal of Clinical Nutrition. 1998; 68 (suppl): 1375S-9S.

Hormonal effects of soy. American Journal of Clinical Nutrition. 1998; 68 (suppl):1531S-3S. Soybean isoflavones: Analysis, amounts in foods and biological matrices, and pharmacokinetics. American Journal of Clinical Nutrition. 1998; 68 (suppl): 1536S-8S.

Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. American Journal of Clinical Nutrition. 1998; 68 (suppl): 1333S-46S.

Black Cohosh

Menopause is a non-event for many women, but for those who suffer symptoms, it is a trying time. Many women are prevented from participating in hormone replacement therapy (HRT) as treatment for menopause, or they simply do not want it. Black Cohosh may provide these women with a safe, cost-effective, and clinically proven alternative.
The cimicifuga plant (Black Cohosh) has been shown in numerous studies to be both safe and effective, and is widely used in Europe and the US to relieve the symptoms commonly associated with PMS and menopause (particularly hot flashes, menstrual cramps, changes to the vaginal lining and even low mood). It also has a long history of use in the US among American Indians. The extract of this plant is sold in great quantities in the US and Europe under the trade name Remifemin. Results of tests comparing Remifemin to combination treatment with estrogens and diazepam have shown treatment with Remifemin to be superior as measured by the Kupperman Menopausal Index. Other tests such as the Self-evaluation For Depression Scale, the Hamilton Anxiety Inventory, and the Clinical Global Impression Scale--all recognized and trusted measures of clinical efficacy--have been used in studies evaluating the performance of Black Cohosh extract, and Black Cohosh has proven itself time and again. In one study, relief of symptoms began in just four weeks in over 80% of test subjects and complete remission of symptoms was achieved in only 6 to 8 weeks for a large percentage of these women!

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Effects of extracts from Cimicifuga racemosa... Planta Medica. 1991; 57(S): 420-424. Black Cohosh. British Herbal Compendium. 1992; Vol 1 British Herbal Medicine Association. Cimicifuga Racemosa. Physicians Desk Reference(PDR) for Herbal Medicines. 1998; 746-7.

Cimicifuga Racemosa (Black Cohosh), German Commission E Official Monograph. March 2, 1989; 90. British herbal composium, Volume 1. Cimicifugae racemosa rhizoma, Bundesahzeiger, no. 43. (March 2, 1989).

Amino Acids and Human Growth Hormone

What is human growth hormone?
Human growth hormone (hGH) is a signaling protein with a specific shape, comprised of 191 amino acids in a unique sequence. Secreted by pituitary, immune, fat and bone cells, hGH promotes growth, regulates the heart and metabolism, and coordinates psychological and physical health. HGH levels decrease significantly with age.

What organs respond best to hGH?
HGH predictably affects the liver, intestines, skin, Islets of Langerhans, prostate and uterus (hormonal). Additionally, hGH targets the heart, brain, eyes, and specific immune cells (nervous and immune). All of these organs decline in health during the aging process. Organs actually shrink in size during the aging process. It is well documented that hGH stimulates organs to return to their original, youthful sizes.

What happens to hGH levels as people age?
The presence of hGH in a healthy adult declines at a rate of about 14% per decade after age 30 and is frequently non-existent by age 80. The American Association of Endocrinology and the American College of Endocrinology suggest that growth hormone deficiency is an age-related event characteristically defined as a cluster of easy to recognize symptoms that include:

Fatigue
Increased weight and abdominal obesity
Decreased lean body mass, muscle mass, and strength
Decreased exercise capacity and physical performance
Cold extremities
Reduced vitality
Impaired sense of well-being
Poor sleep
Emotional instability, anxiety

Is hGH like other hormones?
No, hGH is really a growth factor. Thus, while hGH strengthens bones, helps people grow and regulates metabolism – like other hormones – it also coordinates all immune, nervous and hormonal activities in the mind and body on a regular basis –like growth factors. Growth hormone is secreted by many cells – unlike hormones – and it travels in both the blood and lymph –like growth factors.

How does hGh as a growth factor burn fat?
Growth hormone is actually in the same class of signaling proteins as growth factors. Researchers found that hGH uses the same unique signaling pathways characteristic of growth factors. Just one of more than 40 growth factors, hGH is a multi-potent signaling protein that differs in structure and biological function from all other growth factors. It specifically affects targeted organs to alter metabolism in favor of burning fat and building protein.

What are growth factors?
Growth factors, including growth hormone, comprise the common language used by the immune, nervous and hormonal systems to coordinate activities. You can think of growth factors as emails which quickly guide a cell’s DNA on how to respond to external signals with appropriate cell actions. Growth factors are crucial agents for cellular survival, development, specialization, nutrient uptake, and repair, enabling a cell to be restored in the event of illness, infection, trauma or stress. It is cell signaling that helps prevent aging and heals the body from a multitude of unwanted self-observed chronic symptoms.

STUDY 1

Daniel Rudman, M.D., in the New England Journal of Medicine:

"The effects of six months of human growth hormone on lean body mass and adipose-tissue were equivalent in magnitude to the changes incurred during 10-20 years of aging." Dr. Rudman studied patients age 61 to 81 at the Medical College of Wisconsin-Milwaukee. After six months, Dr. Rudman observed a reversal of the aging process in patients who received HGH injections. The results were to turn back the clock, biologically, as much as 10 to 20 years!

STUDY 2

Dr. Chein of the Life Extension Institute studied 202 patients that he treated with HGH. Patients reported improvement in the following areas:

1. Wrinkle disappearance 61%
2. Skin elasticity 71%
3. Skin & hair care, skin texture 71%
4. Skin thickness 68%
5. Exercise tolerance 81%
6. Overall life outlook 78%
7. Healing capacity 71%
8. Emotional stability 67%
9. Healing of other injuries 61%
10. Back flexibility 83%
11. Muscle size 81%
12. Body fat loss 82%
13. Hot flashes 58%
14. Memory 62%
15. Strength, exercise & body fat, muscle strength 88%
16. Sexual function, potency/freq. 75%
17. Energy level 84%
18. Resistance to common illness 73%
19. New hair growth 38%
20. Duration of penile erection 62%
21. Menstrual cycle regulation 39%